The Position

Group Leader - (Senior) Principal or Distinguished Scientist, Structural Biology

The department of Structural Biology within Genentech Research and Early Development (gRED) has an exciting opportunity for a Group Leader position in structure based drug design to join our team. The successful candidate will lead the structural pursuit of diverse drug discovery targets as well as their independent research. The candidate will work in a highly collaborative environment, embedded in cross-functional teams; therefore, prior successful collaborations are expected. The candidate will use their deep expertise in protein biochemistry, biophysical and computational methods to support structure-based drug design of protein complexes of importance to human diseases. Accordingly, extensive track record of X-ray crystallography and/or Cryo-EM as tools to dissect complex biology and intermolecular interactions is essential.

Who we are:

The Genentech Structural Biology Department integrates macromolecular crystallography, Cryo-EM and NMR spectroscopy to drive drug discovery and uncover fundamental biology. Our department offers a highly interdisciplinary environment with unparalleled resources and unique opportunities for scientific collaboration and growth. We explore the structural and functional properties of proteins of therapeutic interest, and their interactions with ligands, substrates, and binding partners. Our group is involved in every step from construct design and protein purification to structure determination, in-depth analyses and drug design. We collaborate with scientists throughout the Research organization to advance both traditional “small molecule” and protein-based drug discovery as well as to pursue basic research questions regarding structure and function.

Who you are:

• Ph.D. in structural biology, biochemistry, biophysics or related discipline

• Productive postdoctoral and/or industry experience reflected in an established track-record of high impact publications, patents or pipeline project transitions

• A proven track record in optimizing the expression and purification of challenging protein and protein complexes for functional and structural studies is essential

• Strong technical expertise in structure determination by X-ray crystallography (required) and Cryo-EM (desirable)

• Experience level: 4+ years post Ph.D. (Principal Scientist), 8+ (Senior Principal Scientist), 10+ (Distinguished Scientist)

• Experience leading collaborations in cross-functional teams

• Working with chemistry teams in structure based drug design is highly desirable

• Experience with biophysical/biochemical assays for in depth characterization of proteins

• Strong publication record in top tier journals

• Excellent communication, interpersonal and organizational skills

• Fearless attitude to tackle longstanding difficult problems

** Please include a cover letter with your resume submission **

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Relocation benefits are available for this job posting

The expected salary range for this position based on the primary location of California is as follows:

Principal Scientist $119,600-$222,200

Sr. Principal Scientist $143,100-$265,700

Distinguished Scientist $168,600-$313,000.

Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.

Genentech requires all new hires to be fully vaccinated against COVID-19 as of their start date. This requirement is a condition of employment at Genentech, and it applies regardless of whether the position is located at a Genentech campus or is fully remote. If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited as a result of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

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